Once a large percentage of the global population is vaccinated (likely by 2022 or 2023) the earnings potential of the Covid vaccine will diminish. This is an important addition to the manufacturing capacity needed by global pharmaceutical and vaccine companies in the ongoing fight against COVID-19. Other areas? This could potentially limit the use of Pfizer’s vaccine to clinics and hospitals that have the appropriate storage facilities. You can play with assumptions, or try scenarios, as-well-as ask questions to other users and experts. SINGAPORE - The Republic is building up its vaccine-manufacturing capacity even as researchers around the world race to develop one for Covid … The theme is up about 3x over the last 2 years. The stock has more than doubled over the last month as the company began publishing efficacy data. The companies are on track to file an emergency use application with the U.S. FDA later this month if pending data indicates that the vaccine is safe. So how is the company going to meet demand? The company has 21 programs underway, around 13 of which are in the clinical stage. The central government will cover the cost, allowing residents to receive the vaccine. The country is also working to secure deals with American companies. Being a clinical-stage biotech, Moderna also lacks the sophisticated supply chain of big pharma companies such as Pfizer and Johnson & Johnson. See all Trefis Price Estimates and Download Trefis Data here, What’s behind Trefis? Switzerland-based Lonza, one of the world’s largest pharmaceutical services companies, will produce the key mRNA active ingredient for the vaccine in New Hampshire and Switzerland. (related: How Will The Covid-19 Vaccine Impact Moderna’s EPS?) Sanofi is another of the top vaccine manufacturers in the world specialized in research and … But the emergency-use approval comes with restrictions on global distribution. (Photo illustration by Artur Widak/NurPhoto via Getty Images), EY & Citi On The Importance Of Resilience And Innovation, Impact 50: Investors Seeking Profit — And Pushing For Change. Opinions expressed by Forbes Contributors are their own. [5] The speed and the efficacy of the Covid vaccine also indicate that Moderna could leverage this technology to develop new lines of vaccines against a variety of viruses. Led by MIT engineers and Wall Street analysts, Trefis (through its dashboards platform dashboards.trefis.com) helps you understand how a company's products, that you touch, read, or hear about everyday, impact its stock price. For perspective, the Covid-19 vaccine was apparently designed within a few days. All Rights Reserved, This is a BETA experience. Here's what we know about Covid-19 vaccines in Asia Pacific. Several companies already had vaccine platforms targeting other coronaviruses such as MERS and SARS. The vaccine will also be the first to seek emergency use approval from the FDA. Both vaccines will be administered in two doses. Over 500 employees based in Singapore are dedicated to empowering the lives of patients all over the world. | Takeda. (Related: Are Covid Vaccine Stocks Worth Investing In?) While Moderna intends to produce between 500 million to 1 billion doses of its vaccine over 2021, it has no real manufacturing track record and has never produced or sold a commercial drug to date. SII is allowed to produce the Oxford-AstraZeneca vaccine for use within India, but the government has barred them for export until at least March or April -- meaning other countries may have to source their Oxford-AstraZeneca doses from other production sites. ), More importantly for Moderna investors, the vaccine’s results also bode well for the rest of the company’s pipeline, which is entirely based on mRNA technology which has never been used previously in commercial drugs. The two vaccines: The Serum Institute of India (SII) has been manufacturing the vaccine developed by Oxford University and AstraZeneca. Large parts of the rich … The Pfizer-BioNTech vaccine is expected to approved by Australian regulators by the end of January, Morrison said. For example, clinical-stage biotech Moderna (NASDAQ: MRNA), which also uses an mRNA-based technology like the Pfizer vaccine, is slated to report efficacy data in the coming weeks. mRNA-based Covid vaccines focused on the novel coronavirus’ spike protein – which is on the outside of the virus – but there are other viruses whose harmful regions are hidden, making it more difficult for mRNA to address. In fact, we think that the strong data from the vaccine – which is developed using messenger RNA (mRNA) technology could actually mean a lot more for Moderna (NASDAQ: MRNA), another Covid-19 vaccine player, whose entire drug pipeline is based on mRNA technology. See our indicative theme of  Covid-19 Vaccine stocks – which includes U.S.-listed pharma and biotech companies. It did not disclose where the AstraZeneca vaccine would be produced. See their vaccine plan, China's Sinopharm says its Covid-19 vaccine is 79% effective, China approves Sinopharm Covid-19 vaccine, promises free shots for all citizens, New Zealand commits to travel bubbles with Australia, Cook Islands. How Will The Covid-19 Vaccine Impact Moderna’s EPS? The theme is up by about 540% year-to-date versus about 10% for the S&P 500. Pharmaniaga is ready to efficiently distribute Covid-19 vaccines as soon as it receives the go-ahead from the government. The company already has supply agreements with the U.S., Canada, Japan, the U.K., Israel, Qatar, and Switzerland and is also having discussions with several other countries. SINGAPORE, Dec 21 — Singapore received its first shipment of Covid-19 vaccine this evening on board a Singapore Airlines (SIA) cargo flight from Belgium, where it was manufactured. Investors cheered the news, sending Moderna stock up by about 20% on Monday’s trading. For perspective, Pfizer has agreed to supply the U.S. government with the vaccine at about $19.50 per dose, and it’s possible that average prices could be well below this, considering that pricing might be lower in emerging markets. See our indicative theme of  Covid-19 Vaccine stocks – which includes U.S.-listed pharma and biotech companies. While there are two other vaccines by drug majors Pfizer and AstraZeneca that have reported phase 3 results, it looks like Moderna’s vaccine offers the best balance of efficacy and ease of storage and distribution. Australia expects to start administering the first dose in mid-to-late February to priority groups, including quarantine and border workers, frontline healthcare workers, and residents in aged and disability care. Most other countries are still waiting on local regulators to approve vaccine candidates before they can roll out inoculation programs -- and in the meantime, are scrambling to sign deals with pharmaceutical companies to buy the coveted doses in advance. The company could supply about 40 million doses in the United States in 2020 if the data is positive and regulators approve the vaccine. Singapore will begin its voluntary vaccination starting with the Pfizer-BioNTech vaccine, which has been approved by the Health Sciences Authority (HSA) for usage here. Germany’s CordenPharma will produce the lipids – which are used to deliver the mRNA. The country is still evaluating other candidates, including China's. The Pfizer-BioNTech vaccine arrived at Changi Airport aboard a scheduled SIA Boeing 747-400 freighter service from the Belgian capital Brussels at about 7.35pm. Can Senate Handle Trump’s Impeachment And A New Stimulus Package At Once? On Thursday, December 24, 2020, in Dublin, Ireland. Comprised of companies with strong revenue growth, healthy profits, lots of cash, and low risk, it has outperformed the broader market year after year, consistently. : MRNA) published final results from its 30,000-person phase 3 trial of its Covid-19 vaccine and indicated that it would apply for emergency use authorization with the U.S. FDA. Japanese Prime Minister Yoshihide Suga at a press conference in Tokyo on January 4. Although the number could change as more data comes in, it is nevertheless indicative of a highly effective vaccine. The vaccine was over 94% effective in preventing Covid-19 and 100% effective in preventing severe cases of infection – meaning that no one who received the vaccine developed a serve case of the infection. Moderna indicates that it could have about 20 million doses of its vaccine ready by this year and expects to produce between 500 million to 1 billion doses next year in collaboration with Switzerland-based Lonza. While the company had to pause trials in mid-October after an illness was reported in a volunteer, the company is now preparing to resume trials. Moderna (MRNA) , a clinical-stage biotech company, is carrying out phase 3 trials of its Covid-19 vaccine, completing enrollment of 30,000 participants. The theme is up by about 877% year-to-date versus about 14% for the S&P 500. Elderly citizens, health care workers, and those with chronic illness will be first in line to receive a free dose when the initial batch of a million Sinovac doses arrives in January. Overall, Moderna’s vaccine could offer the best of both worlds – high effectiveness and easier logistics, although it could be slightly more difficult to manufacture compared to Pfizer’s. Pfizer’s vaccine is about 95% effective based on phase 3 data, but it needs to be stored at extremely cold temperatures of minus 94 degrees Fahrenheit, calling for specialized freezers. (related: How Will The Covid-19 Vaccine Impact Moderna’s EPS? Japan ranks "among the countries with the lowest vaccine confidence in the world," according to a recent study by The Lancet. Moderna (NASDAQ: MRNA) provided updates on the manufacturing of its Covid-19 vaccine, noting that it was increasing the baseline production estimate for this year to 600 million doses, 100 million more than it had initially projected. Investors have good reason to be optimistic about Moderna for multiple reasons. mRNA offers significant flexibility with vaccine and potentially drug development. STRONG MANUFACTURING PRESENCE IN SINGAPORE. [1] Lonza is also producing the vaccine in the U.S. at its New Hampshire facility. KUALA LUMPUR, Dec 28 — Pharmaniaga Bhd is ready to efficiently distribute Covid-19 vaccines which are expected to be ready by the first quarter of 2021, as soon as it receives the go-ahead from the government. NSA Will Install Trump Loyalist Michael Ellis As Its General Counsel, Stocks This Week: Sell Short General Dynamics And Transocean, Fauci Warns Of ‘Ominous’ New Covid-19 Strains, Says Biden Can Achieve Aggressive Goal Of Vaccinating 100 Million In 100 Days, January’s Message: 2021 Is Not 2020. Chan, however, did not … CAMBRIDGE, Mass.--(BUSINESS WIRE)--Dec. 14, 2020-- Moderna, Inc., (Nasdaq: MRNA) a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today confirmed that the Company concluded an agreement with the Ministry of Health of Singapore to supply mRNA-1273, Moderna’s vaccine … He added that they are working to move up the Pfizer vaccine, to potentially the second quarter. [3]. Prime Minister Jacinda Ardern has said upon approval, the first batches will be delivered to frontline workers and essential staff by the second quarter of 2021. Chinese leaders have promised a growing list of developing countries priority access to its successful vaccines. (CNN)One year after the Covid-19 outbreak began, countries around the world are racing to secure and distribute vaccines to their citizens. Also, vaccines traditionally have lower profitability versus prescription drugs. No Choosing Of Vaccines. The results are surprisingly strong, considering that the U.S. FDA had set a baseline efficacy of just 50% for the approval for Covid-19 vaccines. Novavax (NVAX), a vaccine development company, began late-stage trials of its Covid vaccine in the U.K in September, and large-scale phase 3 trials are due to begin in the U.S. and Mexico this month. (related: How Will The Covid-19 Vaccine Impact Moderna’s EPS?) AstraZeneca’s vaccine, on the other hand, faces concerns regarding some gaps in its trial data, which could undermine its reported results. We maintain strict product-quality standards and multiple supply-chain safeguards to ensure the efficacy, safety and supply of our products - no matter where our medicines and vaccines are manufactured. Not so fast: analysts, After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine. The Oxford-AstraZeneca vaccine could be approved in February. Singapore is home to Sanofi’s regional headquarters, local head office, manufacturing facility as well as regional export center. Other major vaccine makers including Oxford-AstraZeneca, Moderna, and Novavax have also signed deals to provide Japan hundreds of millions of doses in total. (related: A Look At Moderna’s Pipeline Beyond The Covid Vaccine). The stock is down by about -7.6% this year. Called Lunar-Cov19, the vaccine is developed by Duke-NUS Medical School and American pharmaceutical company Arcturus Therapeutics. The country will also secure enough vaccines to cover Pacific Islands including Samoa, Tuvalu, Tokelau, Niue, and the Cook Islands, according to CNN affiliate, Australia's Pfizer doses will be manufactured in the US and Europe, the Oxford-AstraZeneca vaccine will be. Competition is also likely to mount as there are likely to be several more successful vaccine candidates from other companies in the coming quarters. The companies are on track to file an emergency use application with the U.S. FDA later this month if pending data indicates that the vaccine is safe. Moderna’s Covid-19 vaccine could emerge as the most sought-after vaccine, particularly in developed markets – considering the high levels of efficacy as well as manageable refrigeration requirements, unlike Pfizer’s candidate which is also highly effective but needs to be stored at ultra-cold temperatures. SINGAPORE has made arrangements with various pharmaceutical companies to facilitate their clinical trials and drug development in Singapore, with the government having attracted a few players to establish vaccine manufacturing capabilities here. Takeda Vaccines Pte. Data sources: Biotechnology Innovation Organizati… [2], Moderna is working with multiple partners to produce its vaccine. While Moderna has a Covid vaccine of its own in the works, with efficacy data expected any time now, the strong response of Pfizer’s mRNA bodes well not just for Moderna’s Covid efforts, but also for the rest of the company’s sizable pipeline which is focused mostly on vaccines and therapies for rare diseases. The country also secured deals with AstraZeneca and Novavax to secure 50 million doses from each company, but no details were released on when the shipments will arrive. Combined with the large public interest in facilitating vaccine access, these margins may face even more downward pressure. The government agency has invested $45 million to support the manufacturing process of ARCT-021 vaccine. Moderna’s vaccine uses messenger RNA (mRNA) technology – which has never been used in a vaccine before but could be easier to scale up. Chinese Premier Li Keqiang said some Southeast Asian countries would be given priority, including Cambodia, Laos, Myanmar, Thailand and Vietnam. Like Japan, South Korea has yet to approve any vaccine, but has signed contracts with a number of pharmaceutical companies for access to their vaccine candidates. See our indicative theme of  Covid-19 Vaccine stocks – which includes U.S.-listed pharma and biotech companies. Johnson & Johnson (JNJ): Unlike most other vaccine candidates, which are likely to require two shots, J&J is targeting a single-dose vaccine. Using a lower-dose first shot, which conserves the vaccine, and then a full-dose second shot provided protection about 90% of the time, the company and university found. What if you’re looking for a more balanced portfolio instead? While Moderna’s stock trades at about $150 per share, its valuation still looks reasonable at about 25x our projected 2020 EPS. Our indicative theme of Covid-19 Vaccine stocks – which includes a diverse set of U.S.-based pharma and biotech companies developing Covid vaccines – is up by about 560% year-to-date, on an equally weighted basis, compared to the S&P 500 which has gained just about 4% over the same period. However, there are a couple of factors that could help the company scale up quickly. India has authorized two Covid-19 vaccines for use, putting its enormous vaccine-manufacturing capacity in the spotlight. By the end of March, four million people should have been vaccinated, according to Prime Minister Scott Morrison. An illustrative photo showing medical syringes seen in front of Moderna logo displayed on screens in ... [+] the background on Christmas Eve. With enough doses secured for 44 million people, the government is aiming to vaccinate 80% of its population. The company is likely to have efficacy data from late-stage trials available shortly. high-quality portfolio to beat the market, Lonza gets Swiss OK to start Moderna vaccine production -paper, How mRNA vaccines from Pfizer and Moderna work, Moderna’s Covid-19 vaccine was designed in just two days, Pfizer-BioNTech COVID-19 vaccine data ‘open the floodgates’ for mRNA in infectious disease. Some countries like the United States and United Kingdom have already begun vaccinating priority groups and the public. in the U.S., and by ROVI and Recipharm outside the U.S. See our indicative theme of  Covid-19 Vaccine stocks which includes U.S.-listed pharma and biotech companies. [Updated 11/10/2020] What Does Pfizer’s Vaccine Readout Mean For Its Stock?Pfizer (NYSE: PFE) and its German partner BioNTech indicated that their Coronavirus vaccine, dubbed BNT162b2, was over 90% effective at preventing Covid-19 infections among volunteers, based on early data from phase 3 trials. The vaccination card will indicate the vaccine that was administered and the date for the second vaccine dose. On the other hand, vaccines being developed by the likes of Oxford- AstraZeneca, Novavax, and others can be held at regular refrigerated temperatures. China's capabilities mean it could produce vaccines developed by other countries as well. Firstly, the efficacy compares favorably with Pfizer’s Covid vaccine, which reported efficacy of 90%. The company is likely to have data on whether its vaccine works or not by this month, and has noted that it would seek emergency approval from the FDA if the vaccine is at least 70% effective. There are a couple of reasons why Moderna’s vaccine is much sought after. See our indicative theme of  Covid-19 Vaccine stocks – which includes U.S.-listed pharma and biotech companies. This enabled them to rapidly prototype experimental vaccines for immunizing against the novel coronavirus that causes COVID-19. For example, not all viruses are similar to Covid, which mRNA might be better at mimicking. Below is a bit more on the companies in our theme of Coronavirus Vaccine stocks and their relative performance. Among those who have already received the vaccine, fewer than 0.1% developed a light fever, and about two people per million developed "relative serious adverse reactions" such as allergies, according to Zeng. There are still some concerns though. Moderna’s Cytomegalovirus (CMV) vaccine, which is currently in phase 2 studies and could move to phase 3 in 2021, is likely to be the company’s first candidate for approval after its Covid-19 vaccine. Moderna’s vaccine will also be more expensive than rivals, as it is likely to cost between $25 and $37 per dose, depending on the volume of the order, compared to about $19 per dose for the Pzifer vaccine. The vial filling and packaging will be handled by Catalent, a contract manufacturing company. [Updated 12/1/2020]Moderna (NASDAQ This is also the age range recommended by most of the manufacturers and for which the vaccines are approved for use in Singapore by the Health Sciences Authority. The vaccine will be free of charge, with a goal to vaccinate 50 million people ahead of February's Lunar New Year celebrations. Considering that the vaccine is co-developed with BioNTech, any profits will likely be shared. The country will also receive 2 million doses of the Sinovac vaccine in three batches, delivered in February, March and April. Unlike traditional vaccines which use a virus protein that needs to be grown over the course of weeks, mRNA molecules – which instruct the body to produce virus proteins by itself – are less complex and are produced via a chemical process (rather than a biological process) making mass production much quicker. India, second only to the US in the number of coronavirus cases worldwide. The stock is up 253% this year. The vaccine is likely to be priced at between $25 to $37 per dose, with two doses required per person. [Updated 11/17/2020] What The Covid Vaccine Means For Moderna Stock, On Monday, Moderna (NASDAQ: MRNA) stock rallied by over 10% after the company said that its Covid-19 vaccine – which is based on messenger RNA technology – was 94.5% effective based on preliminary data. • In Singapore, the Expert Committee on Immunisation (ECI) recommends the HPV vaccination for females aged nine to 26 years old. [12/10/2020] Can Moderna Rise To The Manufacturing Challenge? the background on Christmas Eve. If Moderna’s success is for some reason limited to certain infectious disease vaccines, its long term outlook might not be as promising, given the lower margins that vaccines typically command. The company has received about $1.6 billion in funding from the Federal government. Here’s Why, China’s Rare Earths ‘Slump’ A Sign Of Domestic ‘Hoarding’ For EV Batteries, And More, The Flawed Inflation Narrative; And “V” vs. “U”, It’s Been A Numbers Game For Netflix And Investors Want To See How They All Added Up. Two shots of the vaccine will be required per person. While Pfizer stock was up by almost 8% following the news, we think it’s unlikely that the vaccine will meaningfully move the needle for the company for multiple reasons. Novartis provides healthcare solutions that improve and extend people’s lives. Arcturus (Nasdaq: ARCT) hopes the compound will prove effective as a vaccine against SARS-CoV-2, the virus that causes COVID-19. On top of this, vaccine manufacturers are required to … Separately, Swiss regulators have reportedly allowed Moderna’s contract manufacturer Lonza Group to start producing its Covid-19 vaccine at a plant in Switzerland, which will apparently have a capacity to produce 800,000 doses a day. The vaccines will be free for the public, Widodo said in December. Firstly, supply will remain an issue in the near-term. With ongoing trials in more than a dozen countries, China will be sending out hundreds of millions of doses in the coming months. A coolroom at Singapore's Changi Airport, preparing for the arrival of its first shipment of Pfizer-BioNTech vaccines, on December 16, 2020. Once the vaccine is produced, the fill-finish operation – which is the process of filling vials and packaging the vaccine for distribution – is handled by Catalent Arcturus Therapeutics announced on Dec. 28 that it received approval from the Singapore Health Sciences Authority to proceed with a Phase 2 clinical study of its vaccine candidate ARCT-021, also known as LUNAR-COV19. The stock is down by -5.1% this year. Some would … The platform uses extensive data to show in a single snapshot what drives the value of a company's business. Surprisingly, the founders of Trefis discovered that along with most other people they just did not understand even the seemingly familiar companies around them: Apple, Google, Coca Cola, Walmart, GE, Ford, Gap, and others. See How It’s Powering New Collaboration and What-Ifs For CFOs and Finance Teams | Product, R&D, and Marketing Teams, Led by MIT engineers and Wall Street analysts, Trefis (through its dashboards platform dashboards.trefis.com) helps you understand how a company's products, that you. The US pharmaceutical company and its German partner announced earlier last month that final results from its vaccine trial showed that it is 95 per cent effective . Both governments have said the vaccines will be free and voluntary for citizens. As well as global, regional and local commercial operations, we have a significant manufacturing presence in Singapore, comprising two global manufacturing supply sites and a vaccines manufacturing facility. [1] The companies intend to manufacture up to 50 million doses this year, and as much as 1.3 billion doses in 2021. [1] The companies … While Pfizer‘s (NYSE: PFE) surprisingly strong initial Covid-19 vaccine efficacy readout likely marks the beginning of the end of the Covid-19 pandemic, it probably doesn’t mean too much for Pfizer stock, given the limited potential profits and challenges with distribution. Gan added that vaccine recipients will also be observed on-site for 30 minutes after receiving their vaccination, so that any severe allergic reactions such as anaphylaxis can be detected and promptly treated. We think it largely is, but there are some risks as well. [4] However, it should be noted that sales of the vaccine will be significantly front-loaded. Sanofi. MSD manufactures medicines and vaccines that are sold in more than 140 countries. The vaccines will be funded by the government and given to priority groups first, including medical workers, military members, the elderly, those with severe diseases, and essential personnel. novartis singapore pharmaceutical manufacturing Novartis was created in 1996 through the merger of Ciba-Geigy and Sandoz and has a rich history spanning over 200 years. For instance, even Pfizer, which also uses mRNA technology and has an established manufacturing base, had to halve its initial vaccine production target for this year to 50 million doses due to some supply chain constraints. While most vaccine stocks declined last week, amid a broader sell-off in the markets, they are likely to come back into the spotlight as efficacy data from late-stage trials is expected from frontrunners Pfizer (NYSE: PFE) and Moderna (NASDAQ: MRNA) in the coming weeks. That’s below the S&P 500 that trades at about 26x projected earnings. 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